NO2U Nitric Oxide Lozenges
60 Lozenges
$59.98
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30-Day Supply
Each package of Lozenges includes 60 lozenges, providing convenient 24-hour coverage when taken twice daily.
How to Use
Nitric Oxide Lozenge: Dissolve one lozenge slowly in your mouth. Do not chew for best results. Move it around your mouth as it dissolves.
- Mouth Sensitivity: If sensitivity occurs due to Vitamin C, you can swish with a baking soda/water mix beforehand. Alternatively, you may chew the lozenge and follow it with water; you will still receive the nitric oxide benefits.
- Hydration: Always maintain adequate hydration to support performance and circulation.
Product Benefits
Our scientifically formulated lozenge is engineered to rapidly release nitric oxide, a critical molecule for athletic performance. Support blood flow, deliver more oxygen and nutrients to working muscles, and push your limits further than ever before.
- Boost Endurance & Stamina: Go longer and finish stronger by improving oxygen delivery and efficiency.
- Enhance Nutrient Absorption: Enhance your body's ability to absorb essential nutrients for better energy and performance.
- Maximize Your Power: Energize your muscles for peak performance and dominate high-intensity intervals with unmatched energy.
- Accelerate Recovery: Improve circulation to help clear metabolic waste and reduce post-workout soreness.
- Support Cardiovascular Health: Promote healthy blood flow and vasodilation to optimize cardiovascular function for overall well-being.
Shipping & Returns
Shipping Information
- Free Shipping: Available for orders $300+ within the continental US.
- Shipping Costs: Economy ($10.25), Expedited ($13.25), and Express ($58.00) options for orders under $300.
- Processing Time: Orders placed before 11:00 AM CST (Mon-Fri) ship within 1 business day, except during high-volume sale periods.
- International Shipping: Available via DHL, Global Access, and UPS. Customs duties and taxes are the responsibility of the recipient.
Returns Policy
- 60-Day Money-Back Guarantee: Returns accepted within 60 days of receipt. Shipping charges are non-refundable.
- Exclusions: Bulk orders (12+ items) and sale items are not eligible for returns.
- Refund Processing: May take up to 30 days, with funds returned within 5-10 business days.
The NO2U Nitric Oxide Lozenge Difference
How It Works
What is Nitric Oxide?
Competitive Edge
Performance Blend
Dr. Bryan
The NO2U Nitric Oxide Lozenge Difference
How It Works
NO2U Nitric Oxide Lozenges deliver an exogenous source of nitric oxide through rapid absorption in your mouth. Benefits include improved circulation, cardiovascular health, enhanced cognitive function, and antioxidant support. Elevate your energy, vitality, and performance daily with NO2U.
How It Works
NO2U Nitric Oxide Lozenges deliver an exogenous source of nitric oxide through rapid absorption in your mouth. Benefits include improved circulation, cardiovascular health, enhanced cognitive function, and antioxidant support. Elevate your energy, vitality, and performance daily with NO2U.
The NO2U Nitric Oxide Lozenge Difference
What is Nitric Oxide?
Nitric Oxide (N.O.), known as the "Miracle Molecule," is essential for oxygen delivery, circulation, cellular communication, and antimicrobial defense. N.O. levels naturally decline with age, dropping to 50% by age 40 and just 15% by age 65, contributing to health issues like cardiovascular disease. Maintaining N.O. supports heart health, cognitive function, energy, and sexual health. Factors like aging, poor diet, and medications can inhibit production, but NO2U provides scientifically-backed solutions to restore this vital molecule and improve overall health.
What is Nitric Oxide?
Nitric Oxide (N.O.), known as the "Miracle Molecule," is essential for oxygen delivery, circulation, cellular communication, and antimicrobial defense. N.O. levels naturally decline with age, dropping to 50% by age 40 and just 15% by age 65, contributing to health issues like cardiovascular disease. Maintaining N.O. supports heart health, cognitive function, energy, and sexual health. Factors like aging, poor diet, and medications can inhibit production, but NO2U provides scientifically-backed solutions to restore this vital molecule and improve overall health.
The NO2U Nitric Oxide Lozenge Difference
Competitive Edge
NO2U leverages nitric oxide to enhance athletic performance by supporting key systems critical to success. It promotes vasodilation to improve oxygen delivery for sustained endurance and optimizes VO2 efficiency for better aerobic capacity. The formula boosts power output during intense activities, enhances muscle pump and vascularity for strength athletes, sharpens mental focus through increased brain oxygenation, and accelerates post-workout recovery by aiding in metabolic byproduct clearance and tissue repair.
Competitive Edge
NO2U leverages nitric oxide to enhance athletic performance by supporting key systems critical to success. It promotes vasodilation to improve oxygen delivery for sustained endurance and optimizes VO2 efficiency for better aerobic capacity. The formula boosts power output during intense activities, enhances muscle pump and vascularity for strength athletes, sharpens mental focus through increased brain oxygenation, and accelerates post-workout recovery by aiding in metabolic byproduct clearance and tissue repair.
The NO2U Nitric Oxide Lozenge Difference
Performance Blend
NO2U Nitric Oxide Lozenges are designed to support cardiovascular health, energy, and vitality by delivering nitric oxide directly to your system. Key ingredients include Vitamin C for antioxidant activity and nitric oxide stability, Magnesium for energy and vascular health, and a NO2U™ Proprietary Blend to boost circulation. The formula also includes Magnesium Ascorbate and Sodium Nitrite to enhance nutrient delivery and blood flow.
What’s NOT Inside: No caffeine, artificial colors, flavors, or unnecessary fillers. This precision formula promotes energy, recovery, and circulation.
Performance Blend
NO2U Nitric Oxide Lozenges are designed to support cardiovascular health, energy, and vitality by delivering nitric oxide directly to your system. Key ingredients include Vitamin C for antioxidant activity and nitric oxide stability, Magnesium for energy and vascular health, and a NO2U™ Proprietary Blend to boost circulation. The formula also includes Magnesium Ascorbate and Sodium Nitrite to enhance nutrient delivery and blood flow.
What’s NOT Inside: No caffeine, artificial colors, flavors, or unnecessary fillers. This precision formula promotes energy, recovery, and circulation.
The NO2U Nitric Oxide Lozenge Difference
Dr. Bryan
Optimize your health with NO2U, developed by leading international leader in molecular medicine and nitric oxide biochemistry, Dr. Nathan S. Bryan. Formulated for both men and women, NO2U helps restore the body's N.O. levels, which decline with age. This supports circulatory health by enhancing blood oxygenation, promoting optimal circulation, and increasing total body vitality. Experience peak performance and stay vital at any stage of life with our expert-backed solutions.
Dr. Bryan
Optimize your health with NO2U, developed by leading international leader in molecular medicine and nitric oxide biochemistry, Dr. Nathan S. Bryan. Formulated for both men and women, NO2U helps restore the body's N.O. levels, which decline with age. This supports circulatory health by enhancing blood oxygenation, promoting optimal circulation, and increasing total body vitality. Experience peak performance and stay vital at any stage of life with our expert-backed solutions.
Product Ingredients
NO2U™ Proprietary Blend
Boost nitric oxide levels and support healthy circulation with our precision-engineered formul... read more
Boost nitric oxide levels and support healthy circulation with our precision-engineered formula.
- Magnesium Ascorbate: Enhances nitric oxide preservation while providing vitamin C and magnesium in one powerful compound.
- Sodium Nitrite: A key nitric oxide precursor designed to promote optimal blood flow and vascular health.
NITRIC OXIDE
BLOOD FLOW
CIRCULATION
IMMUNITY
LONGEVITY
VASCULAR HEALTH
Vitamin C (from Magnesium Ascorbate)
A highly bioavailable, buffered form of vitamin C that supports antioxidant activity and nitri... read more
A highly bioavailable, buffered form of vitamin C that supports antioxidant activity and nitric oxide stability. Gentle on the stomach and designed for superior absorption.
read lessANTIOXIDANT
IMMUNITY
LONGEVITY
VITAMIN C
Magnesium (from Magnesium Ascorbate)
An essential mineral involved in hundreds of cellular processes, including muscle function, en... read more
An essential mineral involved in hundreds of cellular processes, including muscle function, energy metabolism, and vascular support.
read lessCELL FUNCTION
ENERGY
MAGNESIUM
METABOLISM
LONGEVITY
VASCULAR SUPPORT
Other Ingredients
Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltode... read more
Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Modified Food Starch, Starch, Silica, Stevia, Citric Acid, Monk Fruit Extract.
read lessNATURAL FLAVORS
PLANT-BASED
NO2U™ Proprietary Blend
Boost nitric oxide levels and support healthy circulation with our precision-engineered formul... read more
Boost nitric oxide levels and support healthy circulation with our precision-engineered formula.
- Magnesium Ascorbate: Enhances nitric oxide preservation while providing vitamin C and magnesium in one powerful compound.
- Sodium Nitrite: A key nitric oxide precursor designed to promote optimal blood flow and vascular health.
NITRIC OXIDE
BLOOD FLOW
CIRCULATION
IMMUNITY
LONGEVITY
VASCULAR HEALTH
Vitamin C (from Magnesium Ascorbate)
A highly bioavailable, buffered form of vitamin C that supports antioxidant activity and nitri... read more
A highly bioavailable, buffered form of vitamin C that supports antioxidant activity and nitric oxide stability. Gentle on the stomach and designed for superior absorption.
read lessANTIOXIDANT
IMMUNITY
LONGEVITY
VITAMIN C
Magnesium (from Magnesium Ascorbate)
An essential mineral involved in hundreds of cellular processes, including muscle function, en... read more
An essential mineral involved in hundreds of cellular processes, including muscle function, energy metabolism, and vascular support.
read lessCELL FUNCTION
ENERGY
MAGNESIUM
METABOLISM
LONGEVITY
VASCULAR SUPPORT
Other Ingredients
Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltode... read more
Mannitol, Microcrystalline Cellulose, Dextrin, Natural Flavors, Croscarmellose Sodium, Maltodextrin, Stearic Acid, Vegetable Stearate, Modified Food Starch, Starch, Silica, Stevia, Citric Acid, Monk Fruit Extract.
read lessNATURAL FLAVORS
PLANT-BASED
What's Inside Matters
Proprietary Blend • Doctor-Formulated
NO2U Proprietary Blend
Our unique formula delivers highly bioavailable nutrients for maximum impact:
Magnesium Ascorbate: A non-acidic, easily absorbed form of Vitamin C combined with Magnesium, offering the benefits of both in one gentle compound.
Sodium Nitrite: Supports nitric oxide pathways to improve blood flow, oxygen delivery, and nutrient transport to muscles.
Enhance Energy
True energy comes from your cells, not from caffeine or sugar crashes.
Optimizes Oxygen Delivery: Nitric oxide ensures that red blood cells can effectively deliver oxygen to your tissues. More oxygen means your mitochondria (energy factories) can produce more energy.
Reduces Fatigue: By improving the efficiency of nutrient delivery, NO2U helps combat the sluggishness caused by poor circulation, giving you sustainable vitality without the jitters.
NO2U Proprietary Blend
Our unique formula delivers highly bioavailable nutrients for maximum impact:
Magnesium Ascorbate: A non-acidic, easily absorbed form of Vitamin C combined with Magnesium, offering the benefits of both in one gentle compound.
Sodium Nitrite: Supports nitric oxide pathways to improve blood flow, oxygen delivery, and nutrient transport to muscles.
Enhance Energy
True energy comes from your cells, not from caffeine or sugar crashes.
Optimizes Oxygen Delivery: Nitric oxide ensures that red blood cells can effectively deliver oxygen to your tissues. More oxygen means your mitochondria (energy factories) can produce more energy.
Reduces Fatigue: By improving the efficiency of nutrient delivery, NO2U helps combat the sluggishness caused by poor circulation, giving you sustainable vitality without the jitters.
Cardiovascular Health
Your heart works tirelessly to pump blood throughout your body, and nitric oxide is the signal that tells your arteries to relax and open up.
Maintains Healthy Blood Pressure: By promoting vasodilation (the widening of blood vessels), NO2U helps reduce the resistance your heart pumps against, supporting blood pressure levels already within a healthy range.
Supports Arterial Health: Regular nitric oxide production helps keep arteries flexible and youthful, preventing the stiffness often associated with aging.
Healthy Circulation
Circulation is the foundation of overall wellness, affecting everything from your skin to your organ function.
System-Wide Blood Flow: NO2U supports the health of the endothelium—the lining of your blood vessels—ensuring smooth blood flow to every extremity.
Nutrient Transport: Better circulation means that the vitamins, minerals, and hydration you consume are actually delivered to the cells that need them, maximizing the value of your diet and hydration habits.
Cardiovascular Health
Your heart works tirelessly to pump blood throughout your body, and nitric oxide is the signal that tells your arteries to relax and open up.
Maintains Healthy Blood Pressure: By promoting vasodilation (the widening of blood vessels), NO2U helps reduce the resistance your heart pumps against, supporting blood pressure levels already within a healthy range.
Supports Arterial Health: Regular nitric oxide production helps keep arteries flexible and youthful, preventing the stiffness often associated with aging.
Healthy Circulation
Circulation is the foundation of overall wellness, affecting everything from your skin to your organ function.
System-Wide Blood Flow: NO2U supports the health of the endothelium—the lining of your blood vessels—ensuring smooth blood flow to every extremity.
Nutrient Transport: Better circulation means that the vitamins, minerals, and hydration you consume are actually delivered to the cells that need them, maximizing the value of your diet and hydration habits.
US vs Other Brands
With NO2U's nitric oxide supplements, you’re investing in a scientifically advanced solution for better health, energy, and performance. Backed by a 100% satisfaction guarantee, it’s time to make the switch and feel the difference.
Superior Nitric Oxide Production
Scientifically Backed Formula
Enhanced Support and Recovery
Multi-System Benefits
Optimized Dosing
Clean, Natural Ingredients
No Fillers or Stimulants
Plant Based
3rd Party Tested
Delicious Taste & Convenient
From Our Founders
Dr. Nathan Bryan, Founder of NO2U Nitric Oxide
Demonstrates how to take Nitric Oxide Lozenges and how to alkalize your mouth if you're experiencing any mouth sensitivity.
Susan Shaffer, Co-Founder of NO2U Nitric Oxide
Shares her daily routine with Nitric Oxide Lozenges to routine to enhance blood flow, boosts mental clarity, energy, and cognition.
How to Use
1
Training Days
Hydrate before use. Take one lozenge 30-60 minutes pre-workout. For maximum benefit, consider a second dose 12 hours later to support recovery.
2
Off Days
Hydrate before use. Take one lozenge in the morning and one in the evening to maintain optimal nitric oxide production.
3
Stacking
NO2U Nitric Oxide Lozenges can be used with other supplements to maximize their benefits.
4
Mouth Sensitivity
For some, Vitamin C can cause sensitivity. If this occurs, you can swish with a baking soda and water mixture before use to raise oral pH.
Suggested Timing Protocol
Optimize your cardiovascular health and performance with Nitric Oxide Lozenges to unlock their full benefits.
- Daily Use: Take one packet daily to maintain elevated nitric oxide and ATP support for consistent training quality.
- Training Days: Mix one packet in 2-3 oz of water and consume as a shot immediately. For best use, use 10-15 minutes before your workout for maximum effect.
- Race Day: Use as a pre-race shot 20-30 minutes before the start to prime your body for peak output.
Benefits of Daily Use
Wellbeing & Foundational Health
NO2U products are designed to support athletes' foundational health every day, promoting mental clarity, strong bones, a healthy heart, vibrant skin, balanced hormones, and sustained energy—all essential for peak performance.
Immune System
Boost your immune system and stay at the top of your game. NO2U Nitric Oxide Lozenges deliver essential nutrients and support nitric oxide production to help keep you healthy and performing at your best.
Energy Metabolism
Power up your performance with Nitric Oxide. Designed to boost muscle strength and support sustained energy, our advanced formula helps fuel your body for longer, so you can push through every workout and get the most out of every rep.
Muscle Recovery
NO2U’s blend of magnesium and vitamin C helps protect muscles from oxidative stress. This supports efficient nitric oxide production, aiding in enhanced performance and post-workout recovery.
The Performance Timeline
Discover what’s happening in your body when you use a nitric oxide lozenge, from its physiological effects to how it quietly supports your overall health—even if you can’t feel it.
12 Seconds
Blood Flow Kickstart
Blood flow to the brain begins to increase.
1 Minute
Circulation Boost
Vasodilation starts, enhancing circulation throughout the body.
5 Minutes
Initial Performance Boost
Exercise performance can see an initial boost.
10-20 Minutes
Peak Blood Flow
A significant increase in blood flow to the brain and body is achieved. Blood vessels become more flexible, preparing you for the demands of your workout.
60 Minutes
Full Vascular Support
The full effect on vascular function is realized, supporting your entire training session.
4 Hours
Recovery Enhancement
Endothelial function improves by 15-25%, boosting natural nitric oxide production. Increased number of stem cells in circulation improves recovery.
2 Weeks
Improved Blood Flow Regulation
Blood flow regulation improves, enhancing mitochondrial function and exercise capacity.
3 Weeks
Oxidative Stress Reduction
Reduced oxidative stress and inflammation.
1 Month
Cardiovascular Gains
Blood pressure in pre-hypertension and hypertension patients decreases by 12 mmHg systolic and 6 mmHg diastolic, triglycerides drop by 27%, and cardiovascular health improves.
6 Months
Arterial Health Progress
Existing arterial plaque stabilizes and begins to regress by 11%; endothelial function normalizes.
9 Months
Kidney and Heart Health
Kidney function improves, protein excretion decreases, and cardiac function strengthens, including reduced cardiac hypertrophy.
12 Months
Long-Term Health Improvements
Arterial health improves, telomeres stabilize, and antioxidant defenses combat post-meal oxidative stress and inflammation. Cognitive gains include better verbal memory and problem-solving skills.
What sets NO2U products apart?
Clinical Research
Dr. Bryan's Research
Complete Your Stack
Take Your Performance to the Next Level
Fuel your ambition with the smart, science-backed formulas designed for elite athletes and anyone striving to excel their performance.
Frequently Asked Questions
What is Nitric Oxide? Why do I need it?
In 1998, 2 scientists were awarded the Nobel Prize for their discovery that Nitric Oxide acts as a signaling molecule in the cardiovascular system. Nitric Oxide (NO) is a naturally occurring gas in the body that functions as a critical signaling molecule, playing an essential role in regulating various physiological processes.
What are the benefits of Nitric Oxide?
Benefits of nitric oxide include: Improve blood circulation by relaxing blood vessels. Enhancing cognitive function and brain health. Supporting immune function, helping the body fight infections. Promoting skin revitalization, aiding in a youthful appearance. Boosting athletic performance by increasing oxygen delivery to muscles. Enhancing sexual function by increasing dilation of the sex organs providing engorgement.
Are NO2U products backed by science?
Yes! NO2U products are developed using over 25 years of research on Nitric Oxide. They are formulated by Dr. Nathan S. Bryan, a leading expert in the field, ensuring that every product is scientifically tested and effective.
How quickly will I feel it?
Many athletes report feeling a difference in focus, warmth, or "pump" within 10-20 minutes. The primary performance benefits related to endurance and efficiency build over the course of your workout.
Can I use two lozenges per day?
Yes, taking one lozenge twice daily (12 hours apart) is the recommended protocol for maximizing nitric oxide levels for both performance and recovery.
Can NO2U products aid in post-workout recovery?
Yes. By promoting better circulation and oxygen delivery, NO2U products can help reduce muscle soreness and speed up recovery after intense exercise. This makes it easier for athletes to stick to a consistent training schedule with less downtime.
Is NO2U compliant for drug-tested athletes?
Yes. The ingredients in NO2U are not on the WADA Prohibited List. It is a legal, safe way to support your body's natural performance pathways.
How should I time this with my pre-workout caffeine?
You can take NO2U with your normal pre-workout stack. Take it immediately before your session. Since it's not a stimulant, it won't cause jitters.
Does mouthwash impact its effectiveness?
No. The nitric oxide release of the lozenge is not dependent upon oral bacteria so mouthwash will not affect the effectiveness of the lozenge. However, antiseptic mouthwash can disrupt the oral microbiome that is part of the endogenous nitric oxide generation pathway. We recommend avoiding mouthwash to help restore the normal oral flora.
Can I take this with creatine or beta-alanine?
Absolutely. NO2U works via a different mechanism (vasodilation) and is complementary to supplements like creatine (energy production) and beta-alanine (lactic acid buffering).
Will it cause muscle cramps?
NO2U is not typically associated with muscle cramps. In fact, by including magnesium and improving blood flow, it may help support proper muscle function. Always ensure you are adequately hydrated.
